Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer

Depression and pancreatic cancer: a poorly understood link.

Although pancreatic carcinoma and depression have been linked for many years, the prevalence and relationship of these two entities are still poorly understood. Published studies reviewing this issue have found that many patients with pancreatic cancer are depressed. A clinical gestalt asserts that many patients present with depression before pancreatic carcinoma is diagnosed. If the definition...

Thrombosis – Besieged but Poorly Understood

In biology, thrombosis is a mechanism of maintaining the integrity of biological surfaces in higher mammals, limiting fluid loss, and facilitating the recognition, containment, and destruction of pathogens and foreign materials by a scaffold of fibrin and DNA strands. However, thrombosis may also lead to vascular occlusion and subsequent tissue damage. In medicine, thrombosis is a hallmark of l...

Premenstrual asthma: still poorly understood.

Nephrogenic ascites: a poorly understood syndrome.

Nephrogenic ascites is a condition characterized by the presence of massive ascites in a patient with ESRD. Neither the exact cause nor the pathogenesis of ascites formation is clearly understood. Patients frequently present with hypertension, moderate to massive ascites, minimal extremity edema, cachexia, and a history of dialysis-associated hypotension. The ascitic fluid is typically an exuda...

Oligonucleotide microarrays: widely applied--poorly understood.

Microarray technology, which has been around for almost two decades, now provides an indispensable service to the biomedical research community. Soaring demand for high-throughput screening of genes potentially associated with cancer and other diseases, as well as the increased need for identifying microorganisms, have substantially opened up the application of this technology to many fields of...